On Friday, hundreds of people rallied in central Cairo and several other Egyptian cities against President Abdel Fattah al-Sisi, responding to an online call for a demonstration against government corruption.
Egyptian authorities have detained at least 373 people as they try to quash the rare outbreak of protest, rights monitors said on Monday.
The blue-chip stock index fell 1.5% with Commercial International Bank declining 3.5% and Talaat Mostafa Holding plunging 7.6%.
The fall added to the index's previous session loss of 5.3%, its biggest single-day fall since mid-2016 with all its stocks slipping into the red. Non-Arab foreigners were net sellers, according to the stock exchange.
The broader stock index EGX 100 also traded 1.7% lower, hitting its deepest trough since April 2017.
The EGX 100 index slumped 5.7% on Sunday, the most in one day since November 2012, causing trading to be suspended due to a 5% swing for the first time since 2016.
In Dubai, the index snapped a four-day losing streak to rise 0.7%, led by property and banking stocks. Blue-chip developer Emaar Properties gained 1.1% and Dubai Islamic Bank added 1%.
Property developer Deyaar Development advanced 1.2% after an update on a court judgement in a land purchase dispute that came in favour of the company.
Abu Dhabi's index was down 0.9%, with market heavyweight First Abu
Dhabi Bank slipping
1.4% and Emirates Telecommunications Group dropping 1.1%.
Extending losses for a fourth straight day, Qatar's index ended 0.8% lower with the Gulf's largest insurer Qatar Insurance Company declining 4.5%, while Mesaieed Petrochemical was down 3.3%.Saudi Arabia's stock market was closed for National Day.